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Furthermore, hyperuricemia has been shown to activate the renin-angiotensin system, exacerbating hypertension by increasing vascular resistance and fluid retention 35,36

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The H 2 O 2 concentration drives the redox balance in the cell from GSH toward GSSG (see Figure 1) and the increased concentrations of H 2 O 2 and GSSG can modulate many enzymes in one-carbon metabolism (see Section E)

The brain may affect the composition and function of gut microbiota by producing cytokines and antimicrobial peptides, while, through the enteric nervous system and the vagus nerve, bacteria in the gut may transmit signal to the brain and regulate its functioning