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doi:10.1016/s1808-8694(15)31266-0

Thats because semaglutide is a peptide, a type of fragile molecule that can be broken down in the gut

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GLP-1 receptors (GLP-1R) are found in the hypothalamus, (which is vital for functions for the regulation of body temperature, hunger, thirst, sleep-wake cycles, and emotions), the brain stem and the mesolimbic system (a key neural circuit that plays a central role in motivated behaviours, reward processing, and emotional regulation)