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Liraglutide 3.0 mg and Intensive Behavioral Therapy (IBT) for Obesity in Primary Care: The SCALE IBT Randomized Controlled Trial

Zinman, B., Bhosekar, V., Busch, R., Holst, I., Ludvik, B., Thielke, D., Thrasher, J., Woo, V., & Philis-Tsimikas, A

Additionally, the phase 2 MOMENTUM clinical trial of pemvidutide (a dual GLP-1/GCG agonist) showed that only 21.9% of WL was attributable to reductions in lean mass at 48 weeks (overall WL 10.315.6% across doses) [64]

Any potential advantage must be weighed against the well characterised adverse event profile of GLP-1 receptor agonistsincluding gastrointestinal intolerance, gallbladder disease, acute pancreatitis, and other adverse eventswithin a shared, patient centred decision making process that balances individual risk against potential additive gains.1 The observed epidemiological patterns in our study are highly consistent with the known pharmacology and neurobiological mechanisms of GLP-1 receptor agonists

Tolerance develops

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