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Endocr Rev 42(2):101132 McLean BA, Wong CK, Kaur KD, Seeley RJ, Drucker DJ (2021) Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide

However, it is important not to oversimplify the topic

Goal setting your provider will work with you to establish realistic, personalized weight loss goals and a timeline for achieving them
How the company responds, adjusts its product mix, and communicates with regulators and customers could be central to its ability to keep participating in the weight loss category over the longer term

pmid:40015592 28

While there is optimism that continuing use of GLP-1 treatments will preserve weight loss, most other anti-obesity strategies, including surgical interventions, generally have weight recidivism [127]