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VESPER-1: the durability signal In a 32-week exploratory extension (Part B) of VESPER-1, Pfizer reports a 15.9% non-placebo-adjusted weight loss with no plateau observed at 32 weeks on 2.4 mg weekly berobenatide in participants who escalated from placebo to active drug

Resting posterior alpha power and adolescent major depressive disorder

GLP-1 receptors (GLP1R), which are found in pancreatic beta cells as well as other cell types, receive the GLP-1 signal, triggering the release of insulin

It's a tough pill to swallow, but you must discard the vial and start fresh

For treatments that have known serious adverse effects (e.g., anti-amyloid antibody therapies), a personalized approach to treatment needs to include the consideration of the riskbenefit ratio, which may be affected by age, biomarker status, and other risk factors (Boxer and Sperling, 2023)

Step five: the escalation schedule Once you have established your starting dose, follow a 4-week escalation pattern