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GIP Glucose-Dependent Insulinotropic Polypeptide Incretin K (K-cell) (Duodenum) GLP-1 GLP-1 receptor GIP receptor 2 GLP-1 2 GLP-1 (Glucagon-like Peptide-1) GIP (Glucose-dependent Insulinotropic Polypeptide) Mounjaro (Tirzepatide) GLP-1 GIP Mounjaro (Tirzepatide) GLP-1 GIP Dual GIP/GLP-1 Receptor Agonist : : SURMOUNT-1 tirzepatide semaglutide SURMOUNT-5 tirzepatide semaglutide 47% (Rubino et al., 2026, NEJM) : 3 (Triple agonist : GLP-1, GIP, Glucagon) Retatrutide 3 FAQ GLP-1 GIP GLP-1/GIP

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J Biol Chem 2008

Circ Res 118(1):145156

Stabilized propensity score-based IPTW To adjust for baseline patient characteristics between the two groups, the calculated stabilized propensity scores were weighted using the proportion of patients receiving dulaglutide to all patients/propensity score in the dulaglutide group and the proportion of patients receiving liraglutide to all patients/1 propensity score in patients treated with liraglutide as the weighting coefficient on stability 26

Nonetheless, given the heterogeneity of available data and the presence of residual uncertainty, a cautious and individualized clinical approach remains warranted