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[DOI] [PubMed] [Google Scholar] 90.Preventive Services Task Force U.S., Krist A.H., Davidson K.W., Mangione C.M., Barry M.J., Cabana M., Caughey A.B., Donahue K., Doubeni C.A., Epling J.W., Jr., et al

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The inclusion of an anchor lock domain that associates with the S2 extensive subsite enhances its activity approximately 1500fold relative to a fragment that binds only to the S1 and S2 sites