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( 10.1016/S0140-6736(1832261-X) [DOI] [PubMed] [Google Scholar] Hirata K, Kume S, Araki S, Sakaguchi M, Chin-Kanasaki M, Isshiki K, Sugimoto T, Nishiyama A, Koya D, Haneda M, et al

The rubber stopper is an integral part of the vial's sterile barrier system and should never be removed

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Contaminated vials can become dangerous regardless of the BUD

35 The initiation of pharmacotherapy is required for most patients and generally should not be delayed

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