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Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat T2DM have been gradually found to reduce the progression of AD in AD models

Clinical uses Type 2 Diabetes Mellitus (T2DM): Effective in lowering blood glucose without a significant risk of hypoglycemia

Roche's oral small molecule GLP-1 receptor agonist showed positive results in a Phase I trial.

Intention-to-treat analyses resulted in an HR of 1.36 (95% CI 0.51, 3.61)

Lemme GLP-1 Daily combines clinically-studied Supresa saffron, Eriomin lemon extract, and Morosil blood orange for natural appetite control and metabolic support.

Although rare, associations with nonarteritic anterior ischemic optic neuropathy, pancreatitis, medullary thyroid carcinoma, and acute kidney injury (AKI) have been reported, primarily through pharmacovigilance and case-based evidence