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Metformin is a biguanide that lowers hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity

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GLP-1 plays an important role in regulating blood sugar levels, appetite, and digestive function

At Week 26, the primary HbA1c endpoint was missing for 5.6%, 4.2% and 2.5% of patients randomized to placebo, liraglutide 1.8 mg and semaglutide tablets 14 mg, respectively

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