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Agin A, Jeandidier N, Gasser F, Grucker D, Sapin R (2006) Use of insulin immunoassays in clinical studies involving rapid-acting insulin analogues: Bi-insulin IRMA preliminary assessment

The search strategy included combinations of the following keywords: GLP-1 receptor agonists, GLP-1 RA, gut microbiota, microbiome, short-chain fatty acids, bile acids, intestinal barrier, inflammation, and interindividual variability

These results have implications for potentially repurposing GLP-1 RAs as novel therapeutic agents in addiction medicine

A P value 1.5 or FC To investigate the effects of GLP-1R activation on silica-induced pulmonary fibrosis, mice were intratracheally instilled with a single dose of silica, followed by daily treatment with the GLP-1R agonist liraglutide for 56 days

Rats were fed daily to maintain body weight at 90% of free-feeding weight and had ad libitum access to water

In both studies, participants lost around 20% of their body weight Current treatments for sleep apnea target the symptoms of this condition stopped breathing but tirzepatide addresses the underlying cause, blockages in the airway that result in breathing pauses during sleep