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Wilding and his colleagues [Reference ONeil, Aroda, Astrup, Kushner, Lau and Wadden7] conducted a comprehensive analysis by combining data from various weight-management clinical trials [Reference Blackman, Foster, Zammit, Rosenberg, Aronne and Wadden22Reference Wadden, Hollander, Klein, Niswender, Woo and Hale27], focusing on the neuropsychiatric safety of liraglutide

Control groups consisting of five animals each were also included, where formulations were tested in which the active was absent (exenatide study), or in which the vehicle contained active, but propyl gallate was omitted from the formulation (semaglutide)