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Preclinical studies in rodents consistently show reduced alcohol intake with GLP-1 medications, but human clinical trials have produced mixed results

Vomiting: Occured in 22% of patients on semaglutide in the STEP-1 trial, compared to 7.5% in the placebo group

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It is still unclear whether the effect of GLP-1RAs is a result of the direct activation of the hepatic GLP-1 receptor, or an indirect effect caused by weight loss, glycemic control, changes in lipoprotein metabolism, or improved insulin sensitivity [15,34]

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Non-invasive and invasive brain stimulation in alcohol use disorders: a critical review of selected human evidence and methodological considerations to guide future research