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Both meta-analyses and review of the literature indicate that further controlled studies are required to confirm the clinical benefits of high-frequency GES

doi: 10.1503/cmaj.081040

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In addition, GLP-1 can reduce liver cholesterol accumulation by inhibiting SREBP2 and PCSK9, and reduce liver bile acid synthesis by weakening the negative feedback inhibition of bile acid after inhibiting FXR

In this work, therapeutic inertia was observed in nearly 40% of the study population