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Description

Semaglutide restored GSK3-Drp1 signalling, maintained mitochondrial membrane potential, and decreased mitochondrial fragmentation in primary cardiomyocytes via GLP-1R activation

Insurers raised cost-sharing sharply for GLP-1s in recent years and also increased use of prior authorization.

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Sacubitril/valsartan has demonstrated consistent benefits not only in HF with reduced ejection fraction (HFrEF) but also in selected patients with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), especially women and those with borderline left ventricular ejection fraction, as shown in the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) and Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction (PARAGON-HF) trials and supported by Indian ARNI PRESERVED study

GLP-1 medications like semaglutide and tirzepatide are FDA-approved treatments that support sustainable weight loss by regulating appetite, improving insulin sensitivity, and addressing metabolic challenges.