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Furthermore, in streptozocin (STZ i.c.v) -induced AD rats (77) and APP/PS1 mice (78), DPP-4 inhibitors sitagliptin and saxagliptin were observed to have the ability to eliminate A accumulation, clear abnormal phosphorylation of tau, and improve brain mitochondrial dysfunction probably through activation of AMPK in neuronal cells (66)

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These findings collectively support the anti-apoptotic actions of GLP-1RAs as part of their effects on endothelial dysfunction

Renner E, Puskas N, Dobolyi A, Palkovits M