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Therapeutic interventions that simply target hyperglycemia but do not correct the underlying pathogenic disturbances are unlikely to result in a sustained reduction in HbA 1c

Higher concentrations mean smaller injection volumes, which some patients report produces fewer injection-site and systemic GI reactions

Cardiovascular Outcomes Cardiovascular outcomes were assessed in 14 studies

These problems rarely appear in early-stage R&D

Cleve Clin J Med 2017;84:934e42

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