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While our current treatments have shown significant therapeutic benefits, there still appear to be some patients who, despite aggressive therapy, good adherence, and inhaler technique, continue to have exacerbations

For drugs with a narrow therapeutic index, other factors need to be monitored closely, including plasma drug levels, patients clinical outcomes, and laboratory markers

Overall, the study supports current guideline flexibility, indicating that both GLP-1RAs and SGLT2 inhibitors provide broadly similar cardiovascular protection

The significant year-over-year (YoY) jump in GLP-1 coverage among the largest companies signals a key shift: the employer debate is moving from whether to cover weight loss drugs to how to do so sustainably.

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