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One systematic review and meta-analysis found that applying cold to the site before and after a subcutaneous injection of the blood thinner heparin reduced discomfort and bruising

The shortage lifted, but regulators are limiting compounding options due to quality concerns
Switch to tirzepatide if results plateau or side effects are problematic

Ozempic succeeded by proving how important GLP-1 signalling could be

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The SURMOUNT-2 trial in adults with both obesity and type 2 diabetes saw a similar pattern, though weight loss was lower across the board (people with diabetes typically lose less weight on GLP-1 drugs)