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doi: 10.1161/CIRCRESAHA.117.311586

A possible mechanism: GLP-1s appear to dampen dopamine-mediated reward responses , which may be helpful for cravings, but could also blunt some forms of desire, including sexual

Para resolver esse desafio, a estratgia adotada foi manter a estrutura peptdica semelhante a liraglutida e ao GLP-1 endgeno, com uma modificao apenas na posio 8, substituindo Ala por Aib, conhecido por resistir clivagem pelo DPP-IV e ter alta afinidade pelo GLP-1R

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Cardiovascular and Liver Health Improvements Beyond weight loss, this therapy has demonstrated effects on heart and liver health