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Our respondents also thought critically about how these medications intersect with broader culture

The FDA recommends using backup contraception or switching to non-oral methods for four weeks after initiating tirzepatide and for four weeks following each dose escalation to ensure contraceptive reliability during periods of maximum gastric emptying effects

Cochrane Database of Systematic Reviews 2007;2:CD005613

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Research shows this is due to both de novo formation and mast cell degranulation