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It suggests the drug is working reliably through its intended mechanism rather than producing results via a confounding factor

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Even the GLP-1 receptor agonist class, which has actual PCOS trial data and long-standing approvals for diabetes and obesity, is used in PCOS only off-label and with explicit acknowledgment of limited evidence

Understanding GLP-1 Receptor Agonists and Their Action GLP-1 (glucagon-like peptide-1) receptor agonists bind directly to GLP-1 receptors located in the intestines, pancreas, and brain