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Gastrointestinal side effects may include constipation, biliary disease, bowel obstruction or gastroparesis, among others

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If you have type 2 diabetes and use a sulfonylurea (e.g., glipizide, glimepiride, glyburide) or insulin, then consult your primary healthcare provider and/or endocrinologist to ensure the treatment is safe for you with careful monitoring

Large meals combined with slowed gastric emptying (a direct effect of GLP-1 receptor activation) create discomfort, bloating, and nausea

28 Oral administration does not appear to diminish the glucose-lowering or weight-lowering efficacy of semaglutide, 29 with oral semaglutide comparing favorably when studied against the SGLT-2 inhibitor empagliflozin