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Along this line, because of synergistic effects between NAMPT and HDAC inhibitors, dual NAMPT/HDAC inhibitors have been developed and have shown good efficacy in vitro

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However, these findings require replication in larger, randomised controlled trials before definitive conclusions can be drawn

Not only did different animal models such as rats, mice, rabbits and hamsters, help in the discovery and understanding of the therapeutic pathway of GLP-1 drugs, but they also provided crucial data on drug safety, pharmacokinetics and organ-specific effects, all of which were necessary for achieving regulatory approval and the successful translation to human use

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