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CLINICAL PRACTICE CONSIDERATIONS Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

The first few days brought mild bloating as my gut adjusted to the added fiber, which settled by day five

( 10.1007/s12325-023-02750-4) [DOI] [PMC free article] [PubMed] [Google Scholar] Ferdinand KC White WB Calhoun DA Lonn EM Sager PT Brunelle R Jiang HH Threlkeld RJ Robertson KE & Geiger MJ

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Hereby, GLP-1RAs can diminish STAT1 activity [91]

As discussed below, the development of unimolecular multi-agonists that stimulate GLP-1 receptors and other receptors such as GIP receptors and glucagon receptors (GCGR) can have beneficial effects on metabolism and increase metabolic rate at tolerable doses [57]