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An in vivo study in NOX2 knockout mice has shown that knocking out NOX2 completely prevents the cardiovascular and cerebral side effects of e-cigarette smoking
PMID 12679050
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Whats more, nicotine addiction has an anaesthetic effect on the sensory nerves, reducing the smokers ability to fully experience olfactory and gustatory sensations
Getting enough sleep is key too and Ive found CBD oil is helping me feel calmer (one study found smokers taking it consumed 40 per cent fewer cigarettes, suggesting it may help with cravings)
