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The logical solution was clear, at least to Karl and Theo

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In order to verify if acne was always associated with elastotic alterations, we carried out six skin biopsies on smokers affected by acne (mean age 35.6 range 2938 years)

An analysis of 37 different studies suggested that current smokers are 30% more likely to develop dementia and 40% more likely to develop Alzheimers
Popell CA, Burnett RT, Krewski D, Jerrett M, Shi Y, et al