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This study examined the changes in starch, total soluble sugars, total nitrogen, and nicotine at four fermentation time points, which are closely related to the formation of alkaloids, carbohydrates, and proteins (Figures 1BE)

However, conventional accuracy metrics may overestimate clinical utility given this imbalance, as evidenced by the discrepancy between training set performance (XGBoost F1 = 0.808) and validation metrics (F1 = 0.837)

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