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Clinical treatment guideline for tobacco cessation in adults 2024

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A previous study reported that nicotine activates bone marrowderived mast cells (MCs) via 7 nicotinic acetylcholine receptor (7nAChR), and mast cell (MC) deficiency prevents nicotine-induced plaque formation and composition change, implying the important role of MC in nicotine-enhanced atherogenesis in ApoE / mice 18