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Researchers point out that e-cigarette users inhale nicotine in a vapor rather than smoke and claim that, because e-cigarettes do not burn tobacco, they do not expose users to the same levels of chemicals that can cause diseases in people who smoke conventional cigarettes. While the review gleaned insights into potential short-term safety effects, more data on long-term effects is needed, said Hartmann-Boyce

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An adaptive design allowed the early termination of a study that would have been underpowered to detect an effect