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One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30
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[PubMed] [Google Scholar] Takami K, Saito H, Okuda M, Takano M, Inui KI
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Yet, 34 million US adults smoke cigarettes
