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You may do this for a few seconds during a smoke if essential, for example if there is a blockage that you can't otherwise clean, but generally it is strongly recommended to never remove the mouthpiece while the pipe is warm

But there was one exception

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Also eliminated were the fashionable social settings that supported the impression that cigarette smoking was "a go-ahead habit or an essential part of the pleasure and excitement of modern living." Commercials depicting romantic situations that "seemed to link the pleasure of such situations with the pleasures of smoking" were banned

In fact, smokers tend to have lower baseline dopamine levels because their brains have adapted to frequent nicotine intake

Gerald Leon Wallace Endowed Chair of Family Medicine at the University of Alabama School of Medicine