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FIGURE 6 FA-mediated downregulation of miR-34a-5p sensitizes APAP-induced hepatotoxicity in vitro To replicate our in vivo observations, we investigated whether treatment with CS ingredients such as DEN and FA (Smith et al., 2000), affected the severity of APAP-induced hepatocellular death by modulating miR-34a-5p expression in vitro using primary hepatocytes