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The alert was disseminated to regional health authorities, the Italian Society of Emergency Medicine, the Italian Society of Pediatrics, the Italian Society of General Medicine and Primary Care, the Italian Federation of General Practitioners, and to all Poison Control Centers 16

Once released, VIP relaxes smooth muscle, increases intestinal blood flow, and stimulates fluid and electrolyte secretion

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The drug release kinetics can be explained by the Higuchi matrix model, which states that the drug release is controlled by the diffusion of a small liquid into a polymer matrix according to Fickian diffusion