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As the blood flow decreases due to narrowed blood vessels, the working muscles dont get enough oxygen-rich blood when it is needed the most during intense workouts, which means you can get into the anaerobic state (a state where your body starts producing lactic acid, the reason behind the burning sensation felt in the muscles) very easily, which leads to very low endurance

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Dryness, irritability, anxiety, and sleep disturbances may follow

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Nicotine Tob Res 17:127-133, 2015