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Early observations supported that human monocytes exposed to specific flavoring chemicals such as cinnamaldehyde, vanillin, and pentane-dione, found in cinnamon, vanilla, and buttery flavor e-cigarettes, respectively, resulted in a significantly elevated proinflammatory profile [57, 58]

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When you combine these stimulants, youre doubling the vasoconstriction effect , caffeine amplifies adrenaline release while nicotine narrows your blood vessels, reducing cerebral oxygen delivery