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Yet even these strategies face limitations in terms of delivery specificity, metabolic variability among patients, and potential off-target effects

The frequent systemic side effects associated with the use of systemic CAIs may adversely affect compliance

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The most significant activation of the enzymatic antioxidant system was detected in mushrooms stored using modified atmosphere packaging combined with vacuum cooling treatment

For example, reports of enzyme inhibition or modulation of signalling by silymarin derivatives in in vitro systems might partly reflect nonspecific adsorption or redox interference, rather than a real biochemical effect