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nausea and vomiting are the top reasons for discontinuation in clinical trials BPC-157 has demonstrated gastroprotective effects across multiple animal models through three proposed mechanisms: FAK-paxillin mucosal repair, dopaminergic anti-nausea pathways, and vascular support for mucosal perfusion Community co-administration of BPC-157 with semaglutide and tirzepatide is widespread, but no human clinical trial data exists for this combination The Thetis Phase 3 trial (n=280) confirms that pharmaceutical-grade GLP-1 GI side effect management is an active research priority though it does not study BPC-157 specifically Without a structured log of your GI baseline, you cannot evaluate whether any protocol change is actually working Sources Wilding JPH et al