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In a first-in-human clinical trial (NCT02491281), LNA043 was administered via intra-articular injection before total knee replacement, and results showed that LNA043 could reverse the transcriptome signature associated with osteoarthritis by promoting the expression of hyaline cartilage matrix components and anabolic signaling pathways [435]

doi: 10.1093/ajcn/55.2.602s

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Add 5 mL and the concentration becomes 1 mg/mL, making 100 mcg equal to 0.1 mL, or a clean 10 units