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For patients exhibiting low hormone sensitivity but significant OS damage, the focus should shift toward antioxidant therapy while appropriately adjusting the intensity and modality of hormone intervention

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Thus, co-treatment with HDAC and DNMT inhibitors may display significant potential in restoring tamoxifen sensitivity [199]
Cifarelli V., Smith G

10.1007/s11010-021-04306-y 6 AkterK.GulK.MumtazS
