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J Inherit.Metab Dis 2009;32(4):488-497

Meta-analyses of randomized controlled trials indicate that supplementation significantly improves insulin sensitivity, as reflected by reduced HOMA-IR

Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway

While these findings provide mechanistic plausibility for L-carnitine's effects on IR, most evidence derives from animal or cellular models, with limited human histological validation or pathway-intervention studies

Studies suggest it has a direct or indirect antioxidant activity [12]

Nanomicelle-assisted targeted ocular delivery with enhanced antiinflammatory efficacy in vivo