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In the phylogenetic tree, they form a single clade that is close to DHAR, possibly indicating that DHARs derive from GSTIs

In mammals other than man and the great apes, the enzyme uricase breaks uric acid into the more soluble allantoin, which can be more easily excreted in the urine
Especially at this time, when we know clearly that sickle RBC are deficient in anti-oxidant capacity, 15 and that oxidative pathways in RBC promote vasoocclusion, 13 understanding the effects of anti-oxidant therapies on sickle RBC biology, the root cause of SCD, should be prioritized

[DOI] [PubMed] [Google Scholar] 68.Tomofuji T, Ekuni D, Irie K, Azuma T, Endo Y, Tamaki N, et al

Abstract In autoimmune rheumatic diseases, immune hyperactivity and chronic inflammation associate with immune dysregulation and the breakdown of immune self-tolerance

Wood JM, Chavan B, Hafeez I, Schallreuter KU (2004) Regulation of tyrosinase by tetrahydropteridines and H 2 O 2
