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Members of this family were first discovered for their potential of metabolizing an array of toxic exogenous compounds, i.e., xenobiotics via GSH conjugation (Cummins et al., 2011)

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For example, activation of the NLRP3 inflammasome has been shown to play a key role in stimulating neuroinflammation in models of Alzheimers disease, pointing to a microbiotagutinflammasomebrain axis that is crucial for understanding these cross-communication mechanisms [252,253]

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Allergic contact dermatitis occurs in two distinct phases following exposure to haptens like urushiol

A., Sultan T., Osman E