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Peroxynitrite is considered the ultimate oxidant responsible for the mitochondrial membrane permeability transition pore (MPTP) opening, potentially leading to liver cell death [50-52]

Studies have shown that OS markers in the peripheral circulation can reflect central nervous system pathology, as systemic OS may influence brain redox status through altered bloodbrain barrier permeability [43, 44]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP

Unlike regular glutathione, which is often broken down by digestive enzymes in the stomach, the liposomal structure encapsulates and protects it throughout digestion

In the application note Mitochondrial oxidant generation follows oxygen deprivation and re-oxygenation a CLARIOstar equipped with an Atmospheric Control Unit was used to make fluorescence measurements for different probes using either filters or the LVF Monochromator