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Indeed, H 2 O 2 may: (i) irreversibly inhibit the activity of proteins through the over-oxidization of the critical cysteine residues leading to the dysregulation of the intracellular redox signaling and (ii) react with metal-centers present in peroxidases and hemoproteins, favoring the Fenton reaction-driven formation of strong reactive oxidizing species, such as OH, and metal-centered ferryl species

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Tregs are the immune system's peacekeepers