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Molecular Mechanisms of Nutrient-Induced BDNF Regulation Dietary bioactive compounds, including polyphenols, omega-3 fatty acids vitamins, and probiotics, regulate BDNF expression primarily through regulation of major molecular pathways, transcription factors and epigenetic mechanisms related to synaptic plasticity and neuroprotection and functioning upon the modulation of intracellular pathways that primarily involve the MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase) and PI3K/Akt (phosphoinositide-3-kinase/protein kinase B) signaling pathways mediating the downstream signaling effects of CREB (cAMP response element binding) protein, the most recognized transcription factor in controlling gene transcription of BDNF [218]

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The isolated sequence does not occur in full isolation in nature and is produced synthetically for laboratory research purposes

[132] reported elevated expression of AKR1B1 in gastric cancer cells associated with enhanced cell proliferation, migration, and invasion

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GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2