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Metals can be bound to proteins via a specialized and unique arrangement of coordination bonds, integrated into a metallocofactor, either one that is purely inorganic, e.g., in FeS clusters, as part of an organic chelate, e.g., heme or more generally Fe-porphyrin complexes and molybdopterin (Mo), 23 or as a more exotic organometallic cofactor, featuring metalcarbon bonds, and including cobalamin (Co) 99 and nickel pyridinium-3,5-dithiocarboxylic acid mononucleotide (Ni) and others

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These effects are amplified when GHK-Cu is combined with procedures like microneedling or laser resurfacing that create controlled tissue injury and demand a repair response

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