glp 1 receptor brain The gut-brain axis for the actions of glucagon-like peptide-1. After a The evolving story of incretins

Participants in trials like STEP 1 tend to have extreme obesity (average BMI 38) and receive extensive support (including regular lifestyle counseling (source))

Interestingly, weight loss was minimal during the trial, indicating the improvement wasn't simply due to shedding pounds

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Other benefits are still emerging and vary in quality

Moreover, because inflammation and immunosenescence are thought to be common underlying neurodegenerative mechanisms, the potential application of these immune-modulating therapies is not limited to AD and may extend to related dementias, offering promise of disease-agnostic approaches that can prevent or slow neurodegeneration

In summary, GLP-1R agonism decreases homeostatic and hedonic feeding, and modulates food intake not only via the hypothalamus and the hindbrain but also via signaling in the mesolimbic system, in which GLP-1R activation affects reward behavior and palatability