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Using a novel iPSC-based 3-D model that recapitulates human BBB in vitro, a recent study showed that dysregulation of calcineurin/NFAT-signaling in pericytes induces apoE4-associated CAA pathology, whereas inhibition of calcineurin reduces apoE expression and vascular amyloid accumulation [67]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Tamai I, Nakanishi T, Kobayashi D, China K, Kosugi Y, Nezu J, et al