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Cholestatic liver diseases: An era of emerging therapies

10.1001/jamapsychiatry.2021.0380 JAMA Psychiatry

Blam O.G., Vaccaro A.R., Vanichkachorn J.S., Minninch J.M., Albert T.J., Hilibrand A.S., Murphey S.A

One explanation is that while antioxidants can initially protect cells, prolonged exposure might deplete intracellular antioxidant reserves and make cells more susceptible to damage

We included various study types to ensure a broad perspective on the topic, encompassing human clinical trials, animal models, cohort studies, case reports, meta-analyses, systematic reviews, guidelines, editorials, and review articles